Protein Modification Reagents
Medchemexpress LLC Biotin-PEG-azide | 956494-20-5 | MFCD21363314 | 98.7% | 2000.00 | Not specified - polydisperse PEG derivative (no fixed chemical formula) | 50 MG
Biotin-PEG-azide (MW 2000) is a biotin-labeled polyethylene glycol derivative with a terminal azide functional group for bioorthogonal conjugation. The reagent is supplied as a powder and is intended for use in click-chemistry bioconjugation workflows, enabling efficient biotinylation of alkyne-containing molecules and surfaces for downstream affinity capture and detection.
- Contains terminal azide for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC).
- Peg spacer provides hydrophilicity and reduces nonspecific interactions.
- Average molecular weight 2000 Da (polydisperse polymer).
- High purity, suitable for research applications.
- Stable as a powder at -20°C for long-term storage.
- Useful for protein labeling, affinity capture, and general bioconjugation.
Medchemexpress LLC Bis-PEG4-NHS ester | 1314378-11-4 | 97.0% | 488.44 g/mol | C20H28N2O12 | 100 MG
Bis-PEG4-NHS ester is a non-cleavable polyethylene glycol (PEG) linker bearing N-hydroxysuccinimide (NHS) ester reactive groups, designed for bioconjugation and antibody-drug conjugate (ADC) linker chemistry. It couples to primary amines to form stable amide bonds and is supplied as a solid with supporting analytical and handling documentation.
- Non-cleavable 4-unit PEG linker suitable for ADC and bioconjugation
- NHS ester functional groups for efficient coupling to primary amines
- High purity, suitable for research applications
- Solid form, white to off-white appearance
- Stable when stored as powder at -20°C
- Available in multiple pack sizes to support different scales of work
Medchemexpress LLC Pomalidomide-PEG2-acetic acid | 2143097-05-4 | 99.4% | 419.39 | 5 MG
Pomalidomide-PEG2-acetic acid is a chemical conjugate designed for specific biological applications. It functions as an E3 ligase ligand-linker conjugate and is primarily utilized for PROTAC synthesis. This product is intended for research purposes only and is not suitable for medical applications or sale to patients.
- Conjugate composed of an E3 ligase ligand and a linker
- Used for PROTAC synthesis
- For research use only
Medchemexpress LLC DSPE-PEG 2000 | 892144-24-0 | 99.37% | (C2H4O)nC42H82NO10P | 25 MG
DSPE-PEG 2000 is a PEG polymer containing DSPE and amine end groups. It can be used to form micelles as nanoparticles for drug delivery.
- Powder: -20°C for 3 years.
- In solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Phenol-amido-C1-PEG3-N3 (PROTAC Linker 21) | 1096439-18-7 | 99.9% | 50 MG
Phenol-amido-C1-PEG3-N3 is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing Alkyne groups. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent with an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reactions
- Undergoes strain-promoted alkyne-azide cycloaddition reactions
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
![eMolecules N-(Azido-PEG2)-N-PEG4-t-butyl ester | Broadpharm |478.587 | C21H42N4O8 | 90.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCNCCOCCOCCN=[N+]=[N-] | 500mg | 591908394](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183640.JPG-250.jpg)
eMolecules N-(Azido-PEG2)-N-PEG4-t-butyl ester | Broadpharm |478.587 | C21H42N4O8 | 90.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCNCCOCCOCCN=[N+]=[N-] | 500mg | 591908394
N-(Azido-PEG2)-N-PEG4-t-butyl ester | Broadpharm |478.587 | C21H42N4O8 | 90.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCNCCOCCOCCN=[N+]=[N-] | 500mg | 591908394
Medchemexpress LLC Dspe-peg-alkyne | 85.0% | 2000 | 25 MG
DSPE-PEG-alkyne (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. It can be used in drug delivery research.
- Peg lipid
- Improves delivery efficiency
- Enhances tissue specificity for poorly soluble drugs
- Suitable for drug delivery research
Medchemexpress LLC HS-PEG5-CH2CH2NH2 hydrochloride | 1446256-16-1 | 98.0% | 25 MG
HS-PEG5-CH2CH2NH2 hydrochloride is a PROTAC linker belonging to the PEG class, used for synthesizing PROTAC molecules. It is stable under recommended storage conditions and classified as not a hazardous substance or mixture.
- Used for synthesizing PROTAC molecules
- PROTAC linker belonging to the PEG class
- Stable under recommended storage conditions
- Not classified as a hazardous substance or mixture
Medchemexpress LLC Dspe-peg-fitc | 1000788-53-3 | >95.0% | 10000 Da (average) | 10 MG
DSPE-PEG-FITC (MW 10000) is a PEGylated phospholipid conjugated to fluorescein isothiocyanate, designed as an amphiphilic fluorescent lipid for incorporation into liposomes, nanoparticles, or for micelle formation in aqueous solutions. The product is supplied as a solid with an average PEG molecular weight of 10,000 and is used for fluorescent labeling and tracking in drug delivery and nanocarrier research.
- Amphiphilic PEGylated phospholipid suitable for liposome and nanoparticle labeling.
- Fluorescent FITC tag enables visualization and tracking in imaging and biodistribution studies.
- Average PEG molecular weight 10,000 provides steric stabilization and extended circulation properties.
- Forms micelles in aqueous solution for easy incorporation into nanocarriers.
- Solid appearance with recommended storage at -20°C; protect from light (in solvent: -80°C for 6 months, -20°C for 1 month).
Medchemexpress LLC (S,R,S)-AHPC-PEG2-N3 | 2010159-45-0 | 99.9% | 601.72 g/mol | C28H39N7O6S | 5 MG
(S,R,S)-AHPC-PEG2-N3 is an E3 ligase ligand-linker conjugate bearing a terminal azide for click chemistry, used as a building block in PROTAC synthesis and bioconjugation.
- Terminal azide enables copper-catalyzed and strain-promoted azide-alkyne cycloaddition.
- Two-unit PEG linker provides solubility and spacer functionality.
- Designed for conjugation to alkyne, DBCO, or BCN functional partners.
- Supplied in small-quantity formats for research and synthesis workflows.
- Molecular weight 601.72 g/mol; molecular formula C28H39N7O6S.
Medchemexpress LLC Propargyl-PEG4-NHS ester | 1428629-70-2 | MFCD22380743 | 97.0% | 357.36 g/mol | C16H23NO8 | 250 MG
Propargyl-PEG4-NHS ester is a noncleavable four-unit polyethylene glycol (PEG) linker bearing a propargyl (alkyne) group and an N-hydroxysuccinimide (NHS) ester. It is used as a click chemistry reagent to couple azide-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC), and as a PEG-based linker in antibody-drug conjugate synthesis and other bioconjugation applications.
- Noncleavable four-unit PEG linker provides a hydrophilic spacer.
- Terminal propargyl (alkyne) group enables copper-catalyzed azide-alkyne click chemistry.
- NHS ester is amine-reactive for efficient conjugation to primary amines.
- High purity (97.0%) and molecular weight of 357.36 g/mol aid predictable performance.
- Viscous liquid form; recommended storage: pure form -20°C, in solvent -80°C or -20°C.
![Medchemexpress LLC Maytansine, N2'-deacetyl-N2'-[27-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-2,3-dimethyl | 2479378-44-2 | MFCD02066234 | 94.4% | 1297.92 | C68H89ClN6O17 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203439.png-250.jpg)
Medchemexpress LLC Maytansine, N2'-deacetyl-N2'-[27-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-2,3-dimethyl | 2479378-44-2 | MFCD02066234 | 94.4% | 1297.92 | C68H89ClN6O17 | 1 MG
DBCO-PEG4-Ahx-DM1 is a drug-linker conjugate that couples the cytotoxic maytansinoid DM1 to a DBCO-PEG4-Ahx clickable linker for use in antibody-drug conjugate development and conjugation chemistry.
- Intended for antibody-drug conjugate (ADC) construction.
- DBCO functional group enables copper-free click chemistry conjugation.
- PEG4-Ahx spacer provides flexibility and improved solubility.
- Contains DM1 maytansinoid as the cytotoxic payload.
- High purity (≈94.4%).
- Available in small research pack sizes and supplied as a solid.
- Storage: powder -20 °C (stable for 3 years); in solvent -80 °C for 6 months or -20 °C for 1 month.
![eMolecules Cy5-PEG5-NHBoc | BroadpharmMFCD28142459 | 881.590 | C49H73ClN4O8 | 96.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 10mg | 263744685](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502477655.JPG-250.jpg)
eMolecules Cy5-PEG5-NHBoc | BroadpharmMFCD28142459 | 881.590 | C49H73ClN4O8 | 96.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 10mg | 263744685
Cy5-PEG5-NHBoc | BroadpharmMFCD28142459 | 881.590 | C49H73ClN4O8 | 96.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 10mg | 263744685